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Successful treatment of acquired factor VIII inhibitor with cyclosporin
Author(s) -
Au W. Y.,
Lam C. C. K.,
Kwong Y. L.
Publication year - 2004
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2003.00837.x
Subject(s) - medicine , plasmapheresis , cyclophosphamide , treatment modality , antibody , therapeutic modalities , immunology , chemotherapy
Summary. Acquired factor VIII inhibitor causes a rare but life‐threatening form of bleeding disorder, owing to the formation of auto‐antibodies against FVIII. Treatment modalities include the use of immunosuppressive drugs such as cyclophosphamide and corticosteroids, plasmapheresis and i.v. immunoglobulin. A patient with idiopathic acquired FVIII inhibitor presented with serious bleeding complications resistant to all the above therapeutic modalities. Treatment with cyclosporin, however, resulted in a prompt and complete response. The lack of side‐effects and the relatively quick response suggest that cyclosporin may be tried as front line treatment for patients with acquired FVIII inhibitors.