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Acquired factor VIII inhibitor in a non‐haemophilic boy
Author(s) -
Klukowska A.,
Łaguna P.,
ObitkoPłudowska A.,
Niedzielska K.,
Malinowska I.,
RokickaMilewska R.
Publication year - 2003
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2003.00797.x
Subject(s) - medicine , prednisone , surgery , antibody , disease , immunology
Summary. We describe the case of a previously healthy 8‐year‐old non‐haemophilic boy who developed a factor VIII inhibitor of unknown origin. The symptoms of this disease were haemorrhages in the muscles of the right thigh, numerous bruises and a large haematoma of the right crus with subsequent tissue necrosis. Activated and non‐activated prothrombin complex concentrates were administered in the therapy of the haemorrhages. To eliminate factor VIII inhibitor, the patient was treated first with prednisone, then immunoglobulin G and finally with a combination of prednisone and cycylophosphamide, without any effect. A total spontaneous remission was observed after 15 months from the beginning of the disease.