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Management of haemophilia B inhibitor patients with anaphylactic reactions to FIX concentrates
Author(s) -
Shibata M.,
Shima M.,
Misu H.,
Okimoto Y.,
Giddings J. C.,
Yoshioka A.
Publication year - 2003
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2003.00772.x
Subject(s) - medicine , haemophilia b , haemophilia , anaphylactic reactions , protocol (science) , dermatology , haemophilia a , allergy , surgery , intensive care medicine , anaphylaxis , immunology , alternative medicine , pathology
Summary. Allergic reactions to concentrates containing factor IX (FIX) are serious complications in the treatment of haemophilia B patients with inhibitor. We have established a therapeutic protocol for such cases using an initial skin test followed by step‐wise infusions of FIX concentrates under hydrocortisone cover. We have successfully treated three patients whose treatment with FIX had been suspended.