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Successful induction of immune tolerance in a patient with haemophilia B with inhibitor
Author(s) -
Suzuki N.,
Watanabe J.,
Kudoh T.,
Hori T.,
Hatakeyama N.,
Mizue N.,
Oda T.,
Tsutsumi H.
Publication year - 2003
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2003.00754.x
Subject(s) - medicine , haemophilia , factor ix , haemophilia b , haemophilia a , nephrotic syndrome , immune system , immune tolerance , surgery , pediatrics , gastroenterology , immunology
Summary. We describe successful induction of immune tolerance (IT) in a 10‐month‐old boy with severe haemophilia B. Urticaria developed soon after starting prophylactic treatment and was associated with an inhibitor at 7 Bethesda units mL −1 . Initially, we tried low dose factor IX therapy to induce IT with only a transient effect. The patient experienced an intracranial haemorrhage. A simple bolus dose of FIX eradicated the inhibitor. Thereafter he has been free from inhibitor and nephrotic syndrome for more than 5 years, although he receives FIX three times a week.