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Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy
Author(s) -
Parameswaran R.,
Dickinson J. P.,
De Lord S.,
Keeling D. M.,
Colvin B. T.
Publication year - 2000
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2000.00448.x
Subject(s) - medicine , intracranial bleeding , fibrinogen , pediatrics , surgery , intensive care medicine , anticoagulant
Congenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of haemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1 g L −1 and who developed intracranial bleeding are considered. The value of fibrinogen concentrate and the role of prophylaxis is also discussed.