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Pitfalls in the management of a child with mild Haemophilia A and a traumatic hyphaema
Author(s) -
Hallet,
Colin E. Willoughby,
Shafiq,
David M. Kaye,
Bolton-Maggs
Publication year - 2000
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2000.00369.x
Subject(s) - medicine , von willebrand factor , haemophilia , haemophilia a , recombinant dna , surgery , biochemistry , platelet , chemistry , gene
A 12‐year‐old boy presented with a traumatic hyphaema that failed to settle with the standard treatment. Subsequent investigation showed that despite a normal APTT, he had a low factor VIII:C. Treatment with DDAVP precipitated further bleeding despite correction of the fVIII:C to normal, possibly caused by the vasodilation induced by the therapy. Bleeding was effectively treated with recombinant fVIII concentrate. DDAVP may be contraindicated in mild Haemophilia and von Willebrand patients for treatment of traumatic hyphaema.