Premium
The destructive capabilities of the synovium in the haemophilic joint
Author(s) -
Lee C. A.,
Kessler C. M.,
Varon D.,
Martinowitz U.,
Heim M.,
RODRIGUEZMERCHAN E. C.
Publication year - 1998
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.1998.440506.x
Subject(s) - synovitis , medicine , osteoarthritis , synovial joint , synovial fluid , synovial membrane , cartilage , pathogenesis , joint (building) , pathology , articular cartilage , arthritis , anatomy , immunology , architectural engineering , alternative medicine , engineering
Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in.