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Development of a subdural vein thrombosis following aggressive factor VII replacement for postnatal intracranial haemorrhage in a homozygous factor VII‐deficient infant
Author(s) -
Worth L. L.,
Hoots W. K.
Publication year - 1998
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.1998.00181.x
Subject(s) - medicine , coagulopathy , intracranial haemorrhage , thrombosis , factor vii , intracranial hemorrhages , surgery , presentation (obstetrics) , risk factor , pediatrics , venous thrombosis , complication , coagulation , subarachnoid hemorrhage
Congenital factor VII deficiency is a rare (1:500 000) autosomally recessive coagulopathy with variable expression and high penetration. In infants the most devastating presentation is that of intracranial haemorrhage. An infant is described with severe factor VII deficiency who developed post‐natal intracranial haemorrhage. The baby was treated with factor VII concentrate (ImmunoA.G.) ViennaAustria). Three weeks after the haemorrhage he developed a dural venous sinus thrombosis. Although factor VII‐deficient patients may need treatment with factor VII concentrate this needs to be carefully monitored because of the thrombotic risk.