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Presence of human immunodeficiency virus (HIV) and T‐lymphotropic virus type I and II (HTLV‐I/II) in a Haemophiliac population in Belo Horizonte, Brazil, and correlation with additional serological results
Author(s) -
Anna Bárbara F. Carneiro-Proietti,
Maria Virgínia C. Lima-Martins,
Valéria M. A. Passos,
Ricardo Andrade Carmo,
S. R. Pinheiro,
P. R. M. Rocha,
Fernando Augusto Proietti,
Paulo César Peregrino Ferreira,
Vanderson Rocha
Publication year - 1998
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.1998.00128.x
Subject(s) - medicine , serology , virology , population , human t lymphotropic virus , seroprevalence , virus , antibody , immunology , environmental health , myelopathy , psychiatry , spinal cord
The aim of this study was to determine the prevalence of human immunodeficiency virus type 1 (HIV‐1) and human T lymphotropic virus types I and II (HTLV‐I/II) infections in 226 Haemophiliac patients treated at Fundação Hemominas in Belo Horizonte, Minas Gerais State, Brazil, and to verify association with other serological results. Patients positive for HTLV‐I/II had also a neurological, heamatological and ophthalmological evaluation. Fundação Hemominas offers comprehensive care for all Haemophiliac patients in Minas Gerais. Thirty‐six (15.9%) of the 226 patients showed reactive results to HIV‐1 [ELISA, Abbott, USA, confirmed by Western blot (WB), Cambridge Biotech, USA, and/or immunofluorescence, Fiocruz, Brazil] and 16 (7.1%) had reactive sera to HTLV‐I/II (ELISA, Ortho). Eleven of these 16 (4.9%) were positive, 3/16 (1.3%) were indeterminate and 2/16 (0.9%) were negative in the HTLV WB (Cambridge Biotech). Neurological, heamatological and ophthalmological examination of 9/16 patients revealed no abnormality suggestive of HTLV disease. Of the 16 patients reactive to HTLV‐I/II ELISA test, six (37.5%) were also positive to HIV‐1 (χ 2 = 5.92; P = 0.01). Seropositivity for HTLV‐I/II and HIV‐1 was associated with advancing age and positive results for hepatitis C virus (HCV), Chagas’ disease ( T. cruzi infection) and syphilis. No association between the presence of HTLV with type and severity of Haemophilia and hepatitis B results was detected. The prevalence of antibodies against HIV‐1 is approximately three times that of HTLV‐I/II and a patient positive for HTLV‐I/II had a significantly increased risk of being positive for HIV‐1, HCV and T. cruzi .