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Acquired inhibitor to factor VIII: report of two unusual cases
Author(s) -
PATHARE A. V.,
GHAMANDE S.,
FERNANDES S.,
BHATIA S.,
JIJINA F.,
SHETTY S.,
GHOSH K.,
MOHANTY D.
Publication year - 1997
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.1997.00094.x
Subject(s) - medicine , bleed , coagulation , factor ix , haemophilia , autoantibody , pediatrics , surgery , immunology , antibody
Summary . The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX < 1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in de‐veloped countries and is more so in developing countries where treatment options are often limited.