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Transcription termination and anti‐termination in E. coli
Author(s) -
Nudler Evgeny,
Gottesman Max E.
Publication year - 2002
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.2002.00563.x
Subject(s) - biology , transcription (linguistics) , escherichia coli , dna , computational biology , genetics , transcription factor , microbiology and biotechnology , gene , philosophy , linguistics
Transcription termination in Escherichia coli is controlled by many factors. The sequence of the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play a role in determining the efficiency of the process. Termination is regulated and can be enhanced or suppressed by host and phage proteins. This complex reaction is rapidly yielding to biochemical and structural analysis of the interacting factors. Below we review and attempt to unify into basic principles the remarkable recent progress in understanding transcription termination and anti‐termination.