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Roles of nodal‐lefty regulatory loops in embryonic patterning of vertebrates
Author(s) -
Juan Hou,
Hamada Hiroshi
Publication year - 2001
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.2001.00481.x
Subject(s) - biology , nodal , embryonic stem cell , microbiology and biotechnology , nodal signaling , computational biology , embryo , embryogenesis , genetics , gastrulation , gene
Nodal is a signalling molecule that belongs to the transforming growth factor–β superfamily of proteins, and Lefty proteins are antagonists of Nodal signalling. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction‐diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left‐right specification and mesoderm formation. In this review, we will focus on recent studies that have addressed the roles of nodal and lefty in mouse development.