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Molecular basis of tissue‐specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF
Author(s) -
Ito Yoshiaki
Publication year - 1999
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1999.00298.x
Subject(s) - biology , transcription factor , gene , microbiology and biotechnology , core binding factor , genetics , regulation of gene expression , protein subunit
The Runt domain transcription factor PEBP2/CBF is a heterodimer of α and β subunits. Of the three mammalian α subunit genes, which are homologues of the Drosophila gene runt , PEBP2 α A/CBFA1 and PEBP2 α B/AML1 are critical regulators of osteogenesis and haematopoiesis, respectively. A unique functional interaction between PEBP2αB/AML1 and Ets‐1 was recently observed, and provides a clear example of context‐dependent transcriptional regulation. An elaborate mechanism of cooperation between the two factors may represent a basis for tissue‐specific gene expression, which is thought to be achieved by combinations of specific sets of transcription factors unique to each cell lineage or stage of differentiation. A possible molecular basis for the critical role(s) played by PEBP2/CBF in tissue determination is discussed in light of these observations.