Premium
The role of HSP90 in evolution
Author(s) -
Yahara Ichiro
Publication year - 1999
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1999.00271.x
Subject(s) - biology , macroevolution , mutation , phenotype , genetics , mechanism (biology) , evolutionary biology , drosophila (subgenus) , hsp90 , gene , phylogenetics , heat shock protein , philosophy , epistemology
A mechanism by which morphological mutations are stored without expressing phenotypes was unraveled by Rutherford & Lindquist (1998) through genetic studies of Hsp83 (HSP90) in Drosophila . Cryptic mutations are essentially neutral and therefore evolve in the absence of selective constraint. A shift from neutral mutations to selective mutations is induced when flies are exposed to environmental stress. This is a step toward understanding macroevolution in molecular terms.