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Eukaryotic circadian systems: cycles in common
Author(s) -
Dunlap Jay C.,
Loros Jennifer J.,
Liu Yi,
Crosthwaite Susan K.
Publication year - 1999
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1999.00239.x
Subject(s) - biology , circadian clock , negative feedback , circadian rhythm , positive feedback , microbiology and biotechnology , transcription factor , transcription (linguistics) , transcriptional regulation , genetics , feedback loop , domain (mathematical analysis) , computational biology , evolutionary biology , neuroscience , gene , engineering , computer science , electrical engineering , linguistics , philosophy , voltage , mathematical analysis , computer security , mathematics
Common regulatory patterns can now be discerned among eukaryotic circadian systems, extending from fungi through to mammals. Complexes of two distinct PAS domain‐containing transcription factors play positive roles in clock‐associated feedback loops by turning on classic clock proteins such as FRQ, PER and TIM. These in turn appear to act as negative elements, interfering with their own activation and thus giving rise to an oscillatory negative feedback loop. Post‐transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature.