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How protein reads the stop codon and terminates translation
Author(s) -
Nakamura Yoshikazu,
Ito Koichi
Publication year - 1998
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1998.00191.x
Subject(s) - biology , release factor , stop codon , translation (biology) , transfer rna , genetics , mimicry , genetic code , codon usage bias , mechanism (biology) , computational biology , gene , evolutionary biology , genome , messenger rna , rna , ecology , philosophy , epistemology
Translation termination requires two codon‐specific protein‐release factors in prokaryotes and one factor in eukaryotes. The underlying mechanism for stop codon recognition, as well as the biological meaning of the conservation of one or two release factors in the evolutionary kingdoms, are not known. The recent discovery of release factor genes and the molecular mimicry between translational factors and tRNA provide us with clues to the mechanisms of how proteins read the stop codon and terminate translation, shedding some light on the evolutionary aspect of release factors.
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