Premium
Growth phase coupled modulation of Escherichia coli ribosomes
Author(s) -
Wada Akira
Publication year - 1998
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1998.00187.x
Subject(s) - ribosome , biology , escherichia coli , ribosomal protein , ribosomal rna , translation (biology) , stationary phase , 50s , protein biosynthesis , phase (matter) , biophysics , microbiology and biotechnology , biochemistry , rna , messenger rna , physics , gene , chromatography , chemistry , quantum mechanics
Ribosomal modulation factor (RMF), a small basic protein, expresses transcriptionally in the stationary phase of Escherichia coli cells and binds to 50S ribosomal subunits. The RMF bound 70S ribosomes dimerize to form 100S particles that have no translational activity. In transferring the stationary cells to a fresh medium, the 100S particles release the RMF and dissociate to active 70S. The interconversion of ribosomes between active 70S and inactive 100S by RMF is a cellular mechanism controlling translation.