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The role of DNA demethylation during development
Author(s) -
Weiss Alona,
Cedar Howard
Publication year - 1997
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1997.1390337.x
Subject(s) - biology , demethylation , dna demethylation , dna methylation , methylation , gene , genetics , dna , somatic cell , genome , epigenetics , nucleotide , gene expression
The somatic genomic methylation pattern which plays a role in the suppression of basal gene activity is established anew in each generation through developmentally regulated de novo and demethylation steps. Demethylation appears to be carried out by a nucleotide exchange reaction which may involve RNA molecules, and is directed to specific loci in the genome through interactions between cis acting elements and trans acting factors.