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The N‐end rule pathway of protein degradation
Author(s) -
Varshavsky Alexander
Publication year - 1997
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1997.1020301.x
Subject(s) - biology , ubiquitin , ubiquitins , residue (chemistry) , microbiology and biotechnology , biochemistry , bacteria , protein degradation , computational biology , genetics , ubiquitin ligase , gene
The N‐end rule relates the in vivo half‐life of a protein to the identity of its N‐terminal residue. Similar but distinct versions of the N‐end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N‐end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76‐residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N‐end rule pathway.