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Vertebrate non‐receptor protein–tyrosine kinase families
Author(s) -
Neet Kellie,
Hunter Tony
Publication year - 1996
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1996.d01-234.x
Subject(s) - syk , biology , receptor , tyrosine kinase , receptor tyrosine kinase , ror1 , proto oncogene tyrosine protein kinase src , receptor protein tyrosine kinases , microbiology and biotechnology , genetics , platelet derived growth factor receptor , growth factor
Many non‐receptor protein–tyrosine kinases (PTKs) function as subunits of receptors, either receptors with or without intrinsic PTK catalytic activity of their own. There are currently at least 33 known vertebrate genes that encode non‐receptor PTKs. These can be divided into nine families: Abl, Fes/Fer, Syk/Zap70, Jak, Tec, Fak, Ack, Src, and Csk. Four additional non‐receptor PTKs (Rlk/Txk, Srm, Rak/Frk, and Brk/Sik) do not appear to belong to any of the defined families. Here we review current knowledge of the general roles of non‐receptor PTKs, as well as the characteristic features and functions of each family and its family members.