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The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor
Author(s) -
Honjo Tasuku
Publication year - 1996
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1996.10010.x
Subject(s) - biology , transcription factor , multicellular organism , nucleus , microbiology and biotechnology , receptor , transcription (linguistics) , cell , cell nucleus , genetics , gene , linguistics , philosophy
Communication between cell surface receptors and nuclear transcription factors is of primary importance to multicellular organisms. Since there are numerous molecules involved in this process, their mutual interaction forms complex networks of informational regulation, which is still under extensive investigation. The RBP‐Jκ transcription factor interacts directly with the Notch receptor involved in cell lineage commitment, implicating the presence of a uniquely simple communication strategy between the surface receptor and the nucleus.