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Organic anion‐transporting polypeptide (OATP) transporter family and drug disposition
Author(s) -
Kim R. B.
Publication year - 2003
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.33.s2.5.x
Subject(s) - transporter , organic anion transporting polypeptide , efflux , drug , pharmacology , organic anion transporter 1 , organic cation transport proteins , disposition , p glycoprotein , chemistry , gastrointestinal tract , atp binding cassette transporter , solute carrier family , biology , biochemistry , gene , multiple drug resistance , psychology , social psychology , antibiotics
Drug transporters are increasingly recognized as a key determinant of drug disposition. Recent studies have revealed that targeted expression of drug uptake and efflux transporters to specific cell membrane domains allows for the efficient directional movement of many drugs in clinical use. While the role of certain efflux transporters such as MDR1 (P‐glycoprotein) in drug disposition has been extensively studied, emerging evidence suggests that uptake transporters may also be important to the intestinal absorption and renal or hepatic elimination of drugs. Members of the organic anion‐transporting polypeptide (OATP) family of drug uptake transporters have been found capable of transporting a large array of structurally divergent drugs. Moreover, expression of OATP isoforms in the gastrointestinal tract, liver and kidney, as well as at the level of the blood–brain barrier, has important implications for our understanding of the factors governing drug absorption, elimination and tissue penetration.