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Erythropoietin as an angiogenic factor
Author(s) -
Ribatti D.,
Vacca A.,
Roccaro A. M.,
Crivellato E.,
Presta M.
Publication year - 2003
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2003.01245.x
Subject(s) - erythropoietin , erythropoiesis , angiogenesis , signal transduction , kidney , biology , central nervous system , medicine , endocrinology , microbiology and biotechnology , cancer research , anemia
Erythropoietin (Epo) is produced by the fetal liver and adult kidney and is an essential stimulator of erythropoiesis. It has, however, been shown to modulate host cellular signal transduction pathway to perform many other functions. New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions.