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Serum amyloid A and high‐density lipoprotein cholesterol: serum markers of inflammation in sarcoidosis and other systemic disorders
Author(s) -
Salazar A.,
Pintó X.,
Mañá J.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00913.x
Subject(s) - serum amyloid a , sarcoidosis , hypocholesterolemia , medicine , inflammation , rheumatoid arthritis , cholesterol , systemic inflammation , acute phase protein , lipoprotein , endocrinology , immunology
Hypocholesterolemia has been observed in several inflammatory diseases such as rheumatoid arthritis, myeloproliferative disorders, systemic lupus erythematosus and sarcoidosis. Serum amyloid A is an acute‐phase reactant that is related to the high‐density lipoprotein cholesterol. This review discusses the relationship between the activation of the cells of the monocyte‐macrophage system, determined by the serum amyloid A levels, and the lipid metabolism, measured as alterations in plasma lipoprotein concentrations. The mechanisms of this association during acute inflammation are also discussed in this review.