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Effects of short‐term feeding of a highly palatable diet on vascular reactivity in rats
Author(s) -
Naderali E. K.,
Williams G.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00908.x
Subject(s) - medicine , endocrinology , sodium nitroprusside , leptin , obesity , histamine , insulin , endothelium , vasodilation , chemistry , nitric oxide
Background Numerous studies have shown that long‐term consumption of high‐fat, high‐energy diet results in obesity, which in turn, leads to cardiovascular disorders. However, there is little or no data on the acute effects of a highly palatable diet on vascular function. Material and Methods In this study we aimed to evaluate the changes in metabolic and vascular reactivity in Wistar rats fed a palatable diet for 2 days. Results Two‐days feeding of rats with a palatable diet did not effect body weight, fat‐pad mass or gasterocnimus muscles weights. Nor there were any changes in plasma glucose, insulin or leptin levels. However, compared with chow‐fed rats, palatable diet‐fed rats had significantly raised plasma free fatty acids and triglycerides levels (for both, P < 0·01). Compared with chow‐fed animals, vasorelaxation responses to carbamylcholine and sodium nitroprusside were significantly attenuated in palatable diet‐fed rats (for both, P < 0·01). However, there were no differences in histamine‐induced vasorelaxation between chow‐fed and palatable diet‐fed rats. Conclusion These data indicates that diet‐induced endothelium‐dependent and ‐independent vascular dysfunction occurs long before obesity develops.