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Fcγ receptors in autoimmune diseases
Author(s) -
Fossati G.,
Bucknall R. C.,
Edwards S. W.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00881.x
Subject(s) - cd16 , cd64 , receptor , immune system , immunology , fc receptor , immune receptor , biology , opsonin , gene isoform , humoral immunity , immunoglobulin fc fragments , immunoglobulin g , antibody , gene , genetics , cd3 , cd8
Fcγ‐receptors (Fcγ‐R) recognise the Fc portion of IgG and thus form a link between humoral and cellular immunity. These receptors are expressed by a variety of immune cells, and they function in the binding of immune complexes or IgG‐opsonised particles, such as microbial pathogens. The are three major types of Fcγ‐R, namely Fcγ‐RI (CD64), Fcγ‐RII (CD32) and Fcγ‐RIII (CD16), and these differ in their ability to bind IgG and complexes. There are many isoforms of these receptors and a number of recently identified polymorphisms in their structure. This review describes the structure and function of these Fcγ‐Rs, and highlights how gene deficiencies and polymorphisms may contribute to the pathology of human diseases.