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Induction and treatment of the antiphospholipid syndrome – lessons from animal models
Author(s) -
Shoenfeld Y.,
Blank M.,
Sherer Y.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00866.x
Subject(s) - antiphospholipid syndrome , medicine , disease , thrombosis , serology , immunology , pregnancy , intensive care medicine , antibody , transplantation , bioinformatics , biology , genetics
The diagnosis of antiphospholipid syndrome (APS) is based on a combination of clinical and serological criteria. This review summarizes the literature regarding animal models of APS. Animal models of this syndrome help to elucidate pathogenic roles of the characteristic antiphospholipid antibodies in pregnancy morbidity, vascular thrombosis, neurologic disease and atherosclerosis. Furthermore, these models also provide measures to evaluate novel therapies for APS. These include bone‐marrow transplantation, intravenous immunoglobulin, anticoagulation, interleukin‐3, in addition to other therapies. Experimental induction and treatment of APS largely contributes to our understanding of the disease and to better management of its clinical characteristics.