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Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population
Author(s) -
MacLeod M. J.,
De Lange R. P.,
Breen G.,
Meiklejohn D.,
Lemmon H.,
St Clair D.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00851.x
Subject(s) - apolipoprotein e , genotype , stroke (engine) , medicine , allele , population , ischaemic stroke , cardiology , disease , genetics , biology , ischemia , gene , mechanical engineering , environmental health , engineering
Background Apolipoprotein E ε4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have failed to do so. Materials and methods Using PCR and the Taqman fluorescence system to detect polymorphisms we examined apoE genotype in 266 ischaemic stroke cases and in a control population. Results We found no association between apoeE ε 4 allele distribution and ischaemic stroke, or with outcome following stroke as measured using the Rankin score. Conclusion This study disagrees with a recent meta‐analysis, and suggests that further studies are required to clarify the exact relationship between apoE genotype and ischaemic stroke.