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Vasorelaxant effects of oestradiols on guinea pigs: a role for gender differences
Author(s) -
Naderali E. K.,
Smith S. L.,
Doyle P. J.,
Williams G.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00801.x
Subject(s) - mesenteric arteries , medicine , endocrinology , guinea pig , chemistry , artery
Various studies have shown vasorelaxation properties for 17α‐ and 17β‐oestradiol. Here, we studied the effects of gender difference as well as oestrous cycle on oestradiol‐induced vasorelaxation in mesenteric arteries from male and female guinea‐pigs and in main uterine arteries from female guinea‐pigs in vitro . Both 17α‐ and 17β‐oestradiol (0·5–20 µmol L −1 ) induced concentration‐dependent relaxation of both mesenteric and uterine arteries preconstricted with either noradrenaline (NA; 10 µmol L −1 ) or KCl (125 mmol L −1 ) from both day‐7 and day‐15 female guinea‐pigs. 17β‐oestradiol was more potent in relaxing arteries precontracted with NA than those pretreated with KCl, while 17α‐oestradiol was more effective in relaxing those arteries precontracted with KCl. In mesenteric arteries from male animals, 17α‐oestradiol was significantly ( P < 0·001) more potent on arteries precontracted with NA than KCl, an effect opposite to that seen on arteries from female animals. However, both 17α‐ and 17β‐oestradiol were more potent in relaxing arteries from male animals compared with their female counterparts. These data indicate a possible role for gender differences in the vascular effects of oestradiols.