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Increased levels of biochemical markers of bone turnover in relation to persistent immune activation in common variable immunodeficiency
Author(s) -
Ueland T.,
Frøland S S.,
Bollerslev J.,
Aukrust P.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00768.x
Subject(s) - bone remodeling , osteocalcin , proinflammatory cytokine , medicine , endocrinology , n terminal telopeptide , immune system , alkaline phosphatase , tumor necrosis factor alpha , immunology , biology , inflammation , biochemistry , enzyme
Background Based on the involvement of cytokines and growth factors in bone homeostasis, we hypothesised that patients with common variable immunodeficiency (CVI), characterised by persistent immune activation in vivo , may have disturbed bone metabolism as evaluated by biochemical markers of bone turnover. Materials and methods Serum levels of tumour necrosis factor α (TNFα), interleukin‐6 (IL‐6), bone‐specific alkaline phosphatase (B‐ALP), osteocalcin, carboxyterminal crosslinking telopeptide of type I collagen (CTX‐I), insulin‐like growth factor (IGF)‐I and IGF binding protein‐3 (IGFBP‐3) were measured in 25 patients with CVI and compared to 25 age‐ and sex‐matched healthy controls. Results Patients with CVI had significantly higher serum levels of CTX‐I and B‐ALP, and significantly lower serum levels of IGF‐I and IGFBP‐3 compared to controls as shown in cross‐sectional, and as for B‐ALP and CTX‐I, also during longitudinal testing. No differences were observed for osteocalcin between the two groups. The elevated B‐ALP and decreased IGF‐I and IGFBP‐3 levels were most pronounced in a subgroup of CVI patients characterised by persistent activation of proinflammatory cytokines in vivo . Raised B‐ALP and decreased IGF‐I and IGFBP‐3 were also significantly correlated with enhanced IL‐6 and TNF‐α levels in these patients. Conclusions The present study suggests that persistent immune activation in vivo , with raised levels of proinflammatory cytokines, may be related to disturbed bone homeostasis in CVI patients, further supporting an interaction between immune related mediators and bone metabolism in humans.