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Alterations of lipolytic enzymes and high‐density lipoprotein subfractions induced by physical activity in type 2 diabetes mellitus
Author(s) -
Lehmann R.,
Engler H.,
Honegger R.,
Riesen W.,
Spinas G. A.
Publication year - 2001
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2001.00752.x
Subject(s) - medicine , endocrinology , lipoprotein lipase , diabetes mellitus , hepatic lipase , lecithin , high density lipoprotein , cholesterol , enzyme , lipase , lipoprotein , type 2 diabetes , chemistry , biochemistry , adipose tissue
Objective This study investigates the effects of regular moderate physical activity on lipolytic enzymes and plasma lipid concentration, particularly high‐density lipoprotein cholesterol (HDL‐C) subfractions, in patients with type 2 diabetes mellitus. Ten patients participated in a 3‐month exercise programme without any changes in current medical therapy. The control group consisted of six patients who were matched with regard to sex, age, diabetes duration and diabetes therapy. Results Mean (± SE) physical activity in the intervention group increased from 70 ± 21 to 220 ± 28 min per week, which resulted in an increase in total HDL‐C from 1·04 ± 0·07 to 1·28 ± 0·12 ( P < 0·001). The HDL 3 ‐C subfraction increased from 0·71 ± 0·08 to 0·86 ± 0·08 mM ( P = 0·01) with no significant changes in the HDL 2 ‐C subfraction (0·33 ± 0·04 vs. 0·42 ± 0·05). These changes were paralleled by an 85% increase in hepatic lipase (HL) activity, from 25·7 ± 5·1 to 47·4 ± 4·9 µmol mL −1 h −1 ( P < 0·001) and a 45% increase in lipoprotein lipase (LPL) activity, from 16·8 ± 3·0–24·3 ± 2·7 µmol mL −1 h −1 ( P = 0·01). Lecithin‐cholesterol acyl‐transferase (LCAT) activity increased by 32%, from 156 ± 26 to 206 ± 32 nmol mL −1 h −1 ( P < 0·001). In the control group there were no significant changes in any of the variables assessed. Conclusions Regular moderate physical activity in patients with type 2 diabetes led to an overall increase in HL, LPL, and LCAT. HL showed a more pronounced increase than LPL and LCAT. The changes in lipolytic and transferase enzyme pattern resulted in a significant increase of plasma HDL‐C, mainly of the HDL 3 ‐C subfraction.