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Protein sgp 120 as a marker of an acquired angioedema
Author(s) -
Paranos S.,
Nikolic G.
Publication year - 2000
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2000.00705.x
Subject(s) - angioedema , acute phase protein , haptoglobin , hereditary angioedema , medicine , c reactive protein , macroglobulin , immunology , alpha 2 macroglobulin , gastroenterology , inflammation
Background Angioedema is not an event peculiar to an acute‐phase response. We registered the appearance of angioedema in four nonatopic patients suffering from diverse inflammatory stimuli. Materials and methods Serum concentrations of C‐reactive protein (CRP), haptoglobin, α 1 ‐antitrypsin, α 2 ‐macroglobulin, C3, C4, C1INH and protein sgp 120 (classified as a regulatory protein of the complement system) were assessed over 7 consecutive days, beginning with the onset of angioedema in these four patients. Results Instead of returning to the normal level, CRP peaked again on the 4th day ( A ‐test, P < 0.05) and declined significantly by the 7th day ( A ‐test, P < 0.05). Serum levels of sgp 120, C3c and C1INH increased gradually up to the 5th day but only sgp 120 was significantly raised in relation to the initial value ( P < 0.05). Conclusion In our patients, we registered four diverse profiles of the acute‐phase proteins (Kruskal–Wallis test, P < 0.05) probably due to the diverse nature of the pre‐existing inflammatory stimuli. According to these results, the unexpected appearance of angioedema implies the contribution of sgp 120 as the main source of fragments with kinin‐like properties.