Premium
Production and action of transforming growth factor‐β in human osteoblast cultures: dependence on cell differentiation and modulation by calcitriol
Author(s) -
Moustapha Kassem,
Marie Kveiborg,
Erik Fink Eriksen
Publication year - 2000
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.2000.00645.x
Subject(s) - calcitriol , osteoblast , endocrinology , medicine , transforming growth factor , osteocalcin , transforming growth factor beta , chemistry , stromal cell , type i collagen , biology , in vitro , alkaline phosphatase , vitamin d and neurology , biochemistry , enzyme
Transforming growth factor beta (TGF-beta) plays an important role in skeletal remodelling. However, few studies have examined its effects on cultured human osteoblasts. Our aim is to characterise the biological effects of TGF-beta1 on human osteoblasts and to examine the interaction between TGF-beta1 and calcitriol.