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Platelet–collagen interactions: membrane receptors and intracellular signalling pathways
Author(s) -
Lorenzo Alberio,
GL Dale
Publication year - 1999
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1999.00570.x
Subject(s) - integrin , platelet , collagen receptor , microbiology and biotechnology , platelet membrane glycoprotein , signal transduction , intracellular , platelet activation , chemistry , receptor , gpvi , platelet adhesion , adhesion , glycoprotein , biology , biochemistry , immunology , organic chemistry
Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet–collagen interaction support a ‘two‐site, two‐step’ model. Direct platelet binding to integrin α 2 β 1 mainly sustains adhesion and allows recognition of glycoprotein VI. The latter interaction is responsible for characteristic intracellular signalling events leading to p72Syk and PLCγ2 activation. The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.