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NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population
Author(s) -
Hua Cai,
Natalia Duarte,
D. E. L. Wilcken,
X. L. Wang
Publication year - 1999
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1999.00531.x
Subject(s) - nadph oxidase , medicine , coronary artery disease , odds ratio , genotype , gastroenterology , allele , myocardial infarction , population , endocrinology , allele frequency , p22phox , superoxide , cardiology , oxidative stress , genetics , biology , biochemistry , gene , enzyme , environmental health
Background Oxidative stress induced by the superoxide anion (.O 2 − ) has been implicated in atherogenesis. The NADH/NADPH oxidase system is involved in .O 2 − production and p22 phox is an essential component of that system. Material and methods We analysed the p22 phox C242T polymorphism in 689 consecutive Australian Caucasians aged ≤ 65 years with and without angiographically documented coronary artery disease (CAD) Results We report the rare T allele frequency of 0.33, which is 3 fold higher than that reported in the Japanese population by Inoue et al . [7]. The genotype distributions were not different among patients with CAD (CC:0.422, CT:0.459 and TT: 0.119 in men; 0.447, 0.439 and 0.114 in women) and without CAD (0.479, 0.420 and 0.101%, χ 2 = 0.794, P = 0.672 in men; 0.443, 0.471 and 0.86, χ 2 = 0.442, P = 0.802 in women). The frequencies of the rare TT homozygotes or of the ‘T’ allele frequency were also not associated with the number of significantly stenosed vessels (χ 2 = 4.466, P = 0.614 in men; χ 2 = 4.736, P = 0.578 in women) or with a myocardial infarction (MI) history (χ 2 = 2.310, P = 0.315 in men; χ 2 = 1.178, P = 0.555 in women). However, when the analysis was conducted in young male patients aged ≤ 45 years ( n = 44), TT + TC patients tended to have an increased risk for CAD (odds ratio: 5.71 95% CI: 1.22–26.75, P = 0.0271). Conclusion The p22 phox C242T polymorphism is not associated with the occurrence or severity of CAD or with a history of MI in Australian Caucasian patients aged ≤ 65 years. However, the polymorphism could be associated with an increased CAD risk in young patients, which requires confirmation in large populations.