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Peripheral markers of oxidative stress in probable Alzheimer patients
Author(s) -
Repetto,
Reides,
Pablo Evelson,
Kohan,
De Lustig,
Llesuy
Publication year - 1999
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1999.00506.x
Subject(s) - oxidative stress , trolox , catalase , alzheimer's disease , medicine , antioxidant , reactive oxygen species , endocrinology , chemistry , disease , biochemistry , antioxidant capacity
Background The current research on Alzheimer's disease is mainly focused in the post‐mortem characterization of pathological and biochemical alterations in the brain. The finding of peripheral markers that could be associated with the changes observed in the Alzheimer's brain would be of interest in this field. The aim of the present study was to evaluate the state of different peripheral markers of oxidative stress in probable Alzheimer patients and compare them with a group of healthy individuals. Design The determinations made include the plasma total antioxidant capacity (TRAP) and tert‐ butyl hydroperoxide‐initiated chemiluminescence and catalase activity in erythrocytes from 18 patients with probable Alzheimer's disease and 18 matched control subjects with normal cognitive function. Results TRAP was decreased in Alzheimer patients by 24% (control group 308 μmol L −1 Trolox, SEM 34, n = 18). tert ‐Butyl hydroperoxide‐initiated chemiluminescence and catalase activity showed an increase in erythrocytes from Alzheimer patients by 52% (control group 116 700 cps mg −1 haemoglobin, SEM 6690) and 75% (control group 2.55 pmol mg −1 protein, SEM 0.39, n = 18) respectively. Conclusion Oxidative stress in the blood of probable Alzheimer patients could be a reflection of the brain condition and suggests that oxygen free radicals could be partially responsible of the damage observed in this disease.