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Haemodynamic effects of 8‐day octreotide and prazosin administration in portal hypertensive rats
Author(s) -
Lin J,
Kan Wu,
Biao Huang,
Hou,
Myeong Soo Lee,
Hong Li
Publication year - 1998
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1998.00347.x
Subject(s) - octreotide , prazosin , medicine , portal hypertension , portal venous pressure , hemodynamics , anesthesia , endocrinology , somatostatin , antagonist , cirrhosis , receptor
Background Octreotide and prazosin are both effective portal hypotensive drugs in the control or prevention of variceal bleeding. The present study was undertaken to investigate the haemodynamic effects of octreotide and prazosin, alone or in combination, in portal hypertensive rats. Methods Portal hypertension was induced by partial portal vein ligation. Portal hypertensive rats were allocated into one of the four groups — vehicle group (saline, 0.5 mL 12 h −1 ), octreotide group (30 μg kg −1 12 h −1 ), prazosin group (0.4 mg kg −1 12 h −1 ), and octreotide (30 μg kg −1 12 h −1 ) plus prazosin (0.4 mg kg −1 12 h −1 ) group — with eight rats in each group. Prazosin or saline was administered by gavage, whereas octreotide was administered by subcutaneous injection. The drug was given on the day of ligation and continued for 8 consecutive days. Systemic as well as splanchnic haemodynamic parameters were measured thereafter. Results Portal vein‐ligated rats exhibited typical hyperdynamic state compared with sham‐operated rats. The portal venous pressure, portal tributary blood flow and cardiac index were significantly reduced by treatment of octreotide, prazosin or octreotide plus prazosin in portal hypertensive rats. Hyperdynamic parameters of systemic, renal and portal territory vascular resistances, and renal as well as hepatic arterial blood flow were ameliorated by treatment of octreotide or octreotide plus prazosin in portal hypertensive rats. Overall, octreotide treatment exerted more beneficial haemodynamic effects than prazosin treatment. The combination of octreotide and prazosin exerted better haemodynamic effects in cardiac index but worse effects in systemic as well as portal territory vascular resistance than octreotide treatment alone.