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Gelatinases in drug‐induced toxic epidermal necrolysis
Author(s) -
Paquet,
Nusgens,
Piérard,
Lapière
Publication year - 1998
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1998.00329.x
Subject(s) - toxic epidermal necrolysis , drug , medicine , gelatinases , dermatology , pharmacology , matrix metalloproteinase , gelatinase
Background The matrix metalloproteinases (MMPs) MMP2 and MMP9 play a significant role in epidermal detachment, inflammation and re‐epithelialization. We have evaluated their activity in toxic epidermal necrolysis (TEN). Design The level and pattern of activity of MMP2 and MMP9 were investigated by measuring the degradation of 3 H‐labelled gelatin and by zymography in blister fluid from six TEN patients and compared the results with three other blistering conditions: bullous pemphigoid ( n = 6), second‐degree burn ( n = 13) or suction blister ( n = 3). Results A higher amount of MMP2 was found in TEN blister fluid with the constant presence of a significantly larger proportion of the activated forms of MMP2, a particular feature of TEN, than the other blistering diseases studied. Conclusion This study emphasizes the potential role of MMP2 in the specific inflammatory reaction and reparation process in TEN skin.