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Antioxidant defences are reduced during the oral glucose tolerance test in normal and non‐insulin‐dependent diabetic subjects
Author(s) -
Antonio Ceriello,
Nadia Bortolotti,
Adriana Crescentini,
Enrico Motz,
Sebastiano Lizzio,
Assunta Russo,
Z Ezsol,
Laura Tonutti,
C. Taboga
Publication year - 1998
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1998.00295.x
Subject(s) - medicine , endocrinology , antioxidant , diabetes mellitus , uric acid , oxidative stress , vitamin c , vitamin e , insulin , glucose tolerance test , vitamin , chemistry , insulin resistance , biochemistry
Background Free radical production has been reported to be increased in patients with diabetes mellitus, and it has been suggested that hyperglycaemia may directly contribute to the generation of oxidative stress. The aim of the present study was to evaluate the effects of an acute increase in glycaemia on plasma antioxidant defences. Results During the oral glucose tolerance test (OGTT), plasma concentration of protein‐bound sulphydryl (SH) groups, vitamin C, vitamin E and uric acid significantly decreased in normal as well as non‐insulin‐dependent diabetes mellitus (NIDDM) subjects. Total plasma radical‐trapping activity, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual co‐operation, was also significantly reduced. Conclusion This finding supports the hypothesis that hyperglycaemia may, even acutely, induce an oxidative stress.