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Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis
Author(s) -
Reimund Jm,
Allison Ac,
Muller Cd,
Serge Dumont,
Kenney Js,
René Baumann,
Bernard Duclos,
Philippe Poindron
Publication year - 1998
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1998.00257.x
Subject(s) - ulcerative colitis , crohn's disease , immunology , in vitro , inflammatory bowel disease , medicine , disease , proinflammatory cytokine , inflammation , biology , biochemistry
Background Modulation of cytokine secretion may be of interest in the treatment of Crohn's disease or ulcerative colitis. Methods The effect of three antioxidants — butylated hydroxyanisol, tetrahydropapaveroline and nordihydroguaiaretic acid — on the production of tumour necrosis factor (TNF), interleukin (IL) 1, IL‐6 and IL‐8 (measured by enzyme‐linked immunosorbent assay) by peripheral mononuclear cells and biopsies of inflamed colonic mucosa from inflammatory bowel disease patients were studied. Results We observed a decrease in IL‐1 and IL‐6 production by peripheral mononuclear cells from inflammatory bowel disease patients (approximately 50% of control). The three drugs did not decrease IL‐6 and IL‐8 secretion by colonic biopsies, whereas they did inhibit IL‐1 and, to some degree, TNF production. The cytokine‐inhibitory effect of antioxidants seems to be more pronounced in ulcerative colitis than in Crohn's disease. Conclusion Our results suggest that the studied antioxidants, or related compounds, may be of interest in inflammatory bowel disease treatment.