Premium
Release of peptide YY and inhibition of gastric acid secretion by long‐chain and medium‐chain triglycerides but not by sucrose polyester in men
Author(s) -
M.I.M. Maas,
W. P. M. Hopman,
Martijn B. Katan,
J. B. M. J. Jansen
Publication year - 1998
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1998.00255.x
Subject(s) - peptide yy , chemistry , endocrinology , medicine , fatty acid , peptide , sucrose , biochemistry , biology , neuropeptide , neuropeptide y receptor , receptor
Methods In the present study, we have investigated the effects of intraduodenal perfusion of long‐chain and medium‐chain triglycerides and of sucrose polyester on the release of peptide YY in healthy men. Results Perfusion of medium‐chain triglycerides (180 mmol fatty acids) increased the plasma concentration of peptide YY from 7.9 pmol L −1 (SEM 0.2, n = 8) to 10.7 pmol L −1 (SEM 0.5, n = 8), whereas perfusion of long‐chain triglycerides (180 mmol fatty acids) had a significantly greater effect, increasing peptide YY concentration from 8.6 pmol L −1 (SEM 0.2, n = 8) to 18.9 pmol L −1 (SEM 2.4, n = 8, P < 0.008). A smaller quantity of long‐chain triglycerides (90 mmol fatty acids) increased plasma concentration of peptide YY from 7.4 pmol L −1 (SEM 0.4, n = 8) to 13.3 pmol L −1 (SEM 1.5, n = 8), whereas sucrose polyester (90 mmol fatty acids) did not change peptide YY concentration. In a previous study, we investigated gastrin‐stimulated gastric acid output in response to these treatments. The correlation between increases in peptide YY in response to all treatments and the decrease in acid output was r = 0.72 ( n = 48, P < 0.0001). These results show that both long‐chain and medium‐chain triglycerides, but not sucrose polyester, stimulate the release of peptide YY. Conclusion We speculate that peptide YY may play an important role in the inhibition of gastrin‐stimulated gastric acid secretion by long‐chain and medium‐chain triglycerides.