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Gastroduodenal permeability in Crohn's disease
Author(s) -
Püspök,
Oberhuber,
Wyatt,
Maier-Dobersberger,
; Hammer,
Pfeffel,
Wrba,
Pötzi,
Vogelsang
Publication year - 1998
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1998.00241.x
Subject(s) - lactulose , intestinal permeability , gastroenterology , medicine , mannitol , crohn's disease , excretion , disease , chemistry , biochemistry
Background Gastric permeability was prospectively investigated by determination of sucrose excretion in 100 patients with Crohn's disease. Results were compared with histological findings and the lactulose–mannitol ratio as a measure of intestinal permeability. Methods All subjects underwent oesophagogastroduodenoscopy with biopsies of all investigated parts. Thirty‐two Helicobacter pylori‐ positive patients were excluded from further analyses. Results Gastroduodenal permeability was significantly higher in patients with Crohn's disease than in control subjects ( P < 0.00001). Sucrose excretion alone did not predict microscopic inflammation of the upper gastrointestinal tract. Increased gastroduodenal permeability with a concomitant rise in intestinal permeability predicted histological upper gastrointestinal involvement of Crohn's disease with a likelihood of 86%. The negative predictive value was 43%. Conclusion In parallel with findings in the small intestine, gastroduodenal permeability is increased in a high proportion of patients with Crohn's disease. In patients with an increased lactulose–mannitol ratio, elevated sucrose excretion is highly predictive of histological gastroduodenal involvement.