Premium
Both plasma and renal endothelin‐1 participate in the acute cardiovascular response to exercise
Author(s) -
NERI SERNERI G. G.,
CECIONI I.,
MIGLIORINI A.,
VANNI S.,
GALANTI G.,
MODESTI P. A.
Publication year - 1997
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1997.1870736.x
Subject(s) - medicine , endocrinology , plasma volume , endothelin 1 , endothelin receptor , blood volume , kidney , receptor
Plasma endothelin (ET‐1) and renal endothelin are two distinct functional systems involved in maintaining blood volume. To investigate whether plasma and renal ET‐1 participate in the cardiovascular response to exercise‐induced hypovolaemia, we studied changes in plasma and urinary ET‐1 in healthy non‐professional athletes after 2 h of jogging performed both without and with drinking isotonic fluids. After the run, which caused a 13% plasma volume (PV) reduction, plasma and renal ET‐1 (+117% and +118%) increased significantly (all P < 0.01). Fluid loss restitution during the run significantly attenuated either the PV contraction (−1.2%) and plasma and renal ET‐1 increase (+2 and +3%). At multiple regression analysis changes in AVP plasma concentration, and not in PRA or PV per se , were significantly related to ET‐1 changes both in plasma and urine. The present findings indicate that both plasma and renal ET‐1 participate in the cardiovascular response to hypovolaemia induced by long‐lasting, dynamic exercise.