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Lipoprotein lipase gene polymorphisms in ischaemic stroke and carotid stenosis
Author(s) -
HUANG P.,
KOSTULAS K.,
HUANG W.X.,
CRISBY M.,
KOSTULAS V.,
HILLERT J.
Publication year - 1997
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1997.1820730.x
Subject(s) - lipoprotein lipase , stenosis , medicine , cardiology , ischaemic stroke , stroke (engine) , lipase , hepatic lipase , ischemia , biology , enzyme , biochemistry , mechanical engineering , adipose tissue , engineering
Ischaemic stroke is pathogenetically heterogeneous, but there is strong evidence that genetic as well as environment factors contribute to the risk of the individual. Here we report the similar distribution of polymorphic markers of the lipoprotein lipase ( LPL ) gene in 128 patients with ischaemic stroke, 56 patients with carotid artery stenosis and 95 healthy control subjects, in spite of a significant influence of the Asn291→ Ser mutation on serum levels of triglycerides. We conclude that these LPL polymorphisms do not contribute greatly to the overall risk of ischaemic stroke in the general population.