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Structural and compositional modifications of diabetic low‐density lipoproteins influence their receptor‐mediated uptake by hepatocytes
Author(s) -
KRÄMERGUTH A.,
QUASCHNING T.,
GALLE J.,
BAUMSTARK M. W.,
KÖNIGER M.,
NAUCK M.,
SCHOLLMEYER P.,
MÄRZ W.,
WANNER C.
Publication year - 1997
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1997.1460695.x
Subject(s) - glycation , apolipoprotein b , medicine , endocrinology , diabetes mellitus , pathogenesis , ldl receptor , chemistry , receptor , lipoprotein , cholesterol , in vivo , intracellular , biochemistry , biology , microbiology and biotechnology
Dyslipoproteinaemia is an important risk factor for the development of atherosclerosis in non‐insulin‐dependent diabetes mellitus (NIDDM). This study shows that the uptake of low‐density lipoproteins (LDLs) prepared from the plasma of patients with NIDDM in cultured human hepatoma cells is largely reduced. In addition, diabetic LDL was less effective in suppressing intracellular cholesterol synthesis. This is because of physicochemical and biochemical differences between lipoproteins from diabetic and from normal individuals. LDL from patients with NIDDM was abnormal with regard to charge, the degree of glycation, the lipid composition and the conformation of the apolipoprotein B receptor‐binding domain. The diminished receptor‐mediated uptake of apolipoprotein B‐containing lipoproteins in diabetic individuals most probably leads to the accumulation of these lipoproteins in vivo and may be of great importance to the pathogenesis of atheroclerosis in these patients.