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Plasma endothelin‐1 levels during transient acute myocardial ischaemia in men: effects of coronary revascularization
Author(s) -
FERRI C.,
DE MARZIO P.,
DESIDERI G.,
BALDONCINI R.,
BELLINI C.,
MORELLI S.,
SANTUCCI A.
Publication year - 1997
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1997.1410685.x
Subject(s) - medicine , dipyridamole , cardiology , revascularization , endothelin receptor , endothelin 1 , angina , coronary artery disease , endothelium , ischemia , myocardial infarction , receptor
The endothelium‐derived peptide endothelin‐1 (ET‐1) was evaluated in 14 male patients [mean age 52.74 years (SEM 1.10)] affected by coronary artery disease during a bicycle electrocardiographic stress test and dipyridamole echocardiogram. Both tests were performed before and after coronary revascularization. Fourteen healthy male subjects served as controls [mean age 53.21 years (SEM 1.63)]. Baseline plasma endothelin‐1 levels were higher ( P < 0 . 0001) in ischaemic patients [1 . 81 pg mL −1 (0 . 15, n = 14)] than in control subjects [0 . 61 pg mL −1 (0 . 03, n = 14)], but did not increase with exercise in both groups. Similar results were obtained with dipyridamole infusion. Endothelin‐1 levels significantly decreased after coronary revascularization [before: mean 1 . 81 pg mL −1 (SEM 0 . 15, n = 14); after: mean 1 . 16 pg mL −1 (SEM 0 . 11), P < 0 . 002], without changes in the peptide response to both tests. In conclusion, elevated plasma endothelin‐1 concentrations were found in patients with stable angina compared with non‐ischaemic subjects. No changes were observed during exercise or dipyridamole infusion in both groups. Coronary revascularization was followed by a significant decrease in plasma endothelin‐1 levels.