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Altered release of endothelin‐1,2 and thromboxane B 2 from trophoblastic cells in pre‐eclampsia
Author(s) -
CERVAR M.,
KAINER F.,
JONES C. J. P.,
DESOYE G.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1996.87238.x
Subject(s) - thromboxane b2 , endocrinology , medicine , radioimmunoassay , leukotriene b4 , thromboxane , angiotensin ii , thromboxane a2 , chemistry , endothelin receptor , endothelin 1 , endothelins , alpha (finance) , prostaglandin , platelet , blood pressure , receptor , inflammation , construct validity , nursing , patient satisfaction
The aim of the study was to investigate whether pre‐eclampsia is associated with an altered release of vasoactive substances from trophoblastic cells in vitro . Trophoblastic cells from 15 uncomplicated control pregnancies and 18 pre‐eclamptic pregnancies at preterm (weeks 31–36; n = 12) and term (weeks 37–40; n = 21) were cultured for 5 days. The concentrations of angiotensin II (AII), endothelin‐1,2 (ET‐1,2), thromboxane B 2 (TXB 2 ), 6‐keto‐prostaglandin F 1α (6‐keto‐PGF1 α ) and leukotriene B 4 (LTB 4 ) were measured daily in culture media for 5 days by radioimmunoassay. In pre‐eclampsia, concentrations of ET‐1,2 were decreased ( P < 0.01) at both preterm and term, TXB 2 concentrations were increased P < 0.05) only at preterm and the TXB 2 –6‐keto‐PGF 1α ratio was increased at both preterm and term ( P < 0.01) as compared with the controls. Concentrations of AII, 6‐keto‐PGF 1α and LTB 4 were similar to the controls. The data suggest that pre‐eclampsia is associated with a decreased release of ET‐1 and an increased release of TXB 2 from trophoblastic cells in vitro