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Cytokine profile in chronic cardiac failure
Author(s) -
STEELE I. C.,
NUGENT A.M.,
MAGUIRE S.,
HOPER M.,
CAMPBELL G.,
HALLIDAY M. I.,
NICHOLLS D. P.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1996.2560587.x
Subject(s) - medicine , cytokine , tumor necrosis factor alpha , cachexia , interleukin 6 , receptor , interleukin , inflammation , gastroenterology , immunology , cancer
Elevated tumour necrosis factor α (TNF‐α) has been demonstrated in chronic cardiac failure (CCF) and may relate to severity of CCF and development of cachexia. We measured TNF receptor p55 in addition to TNF‐α in an attempt to improve the detection rate of TNF‐α activation, and simultaneously measured interleukin 6 (IL‐6), interleukin 8 (IL‐8) and C‐reactive protein. Thirty‐four patients with CCF and 24 control subjects were studied. Only TNF receptor p55 [6.95 (0.77−42.3) vs. 5.52 (1.50−13.36) ngmL −1 (median (range)] and IL‐6 [0.335 (0−9.79) vs. 0 (0−14.71) pgmL −1 ) were significantly elevated in patients compared with control subjects (both P <0.05). All inflammatory markers were more frequently elevated in patients, but none correlated with any of the clinical parameters studied. Reasons for inflammatory marker elevation in CCF are uncertain, but future studies should measure the p55 TNF receptor and IL‐6 in addition to TNF‐α, to improve detection of cytokine activity.