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Endothelium activation related increase of soluble intercellular adhesion molecule‐1 in human schistosomiasis. Lack of correlation with serology
Author(s) -
LEJOLYBOISSEAU H.,
BLANN A. D.,
SEIGNEUR M.,
TRIBOULEYDURET J.,
TRIBOULEY J.,
BOISSEAU M. R.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1996.192320.x
Subject(s) - schistosomiasis , serology , schistosoma mansoni , endothelium , intercellular adhesion molecule 1 , immunology , adhesion , endothelial activation , intracellular , icam 1 , biology , cell adhesion molecule , medicine , antibody , chemistry , helminths , microbiology and biotechnology , organic chemistry
Soluble intercellular adhesion molecule‐1 (sICAM‐1) level was measured in sera from 41 patients with Schistosoma mansoni schistosomiasis and compared with the sICAM‐1 level in 41 healthy subjects. A significant increase in serum sICAM‐1 was observed in patients with schistosomiasis compared with control subjects. As they were inhabitants of the French Antilles, the patients were, however, not settled in a malaria endemic zone, allowing this cause of sICAM‐1 enhancement to be eliminated. No correlation was found between the level of sICAM‐1 and the schistosomiasis serological titre. Such results favour the hypothesis of an activation of vascular endothelial cells due to egg deposition.