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Elevated plasma adrenomedullin level in hyperthyroidism
Author(s) -
TANIYAMA M.,
KITAMURA K.,
BAN Y.,
ETO T.,
KATAGIRI T.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1996.155307.x
Subject(s) - adrenomedullin , euthyroid , medicine , endocrinology , hemodynamics , vasodilation , vascular resistance , blood pressure , hormone , receptor
Adrenomedullin is a recently discovered peptide that was first purified from phaeochromocytoma tissue and has marked vasodilatory activity, causing hypotension. In thyrotoxicosis, various haemodynamic changes are observed, including an increase in cardiac output and heart rate with a concomitant decrease in peripheral vascular resistance. To evaluate the mechanism underlying these haemodynamic changes in thyrotoxicosis, we measured the plasma adrenomedullin concentration in thyrotoxic patients with Graves' disease. The plasma concentration of adrenomedullin was elevated in hyperthyroid patients (14.7±5.7pmolL −1 ) compared with euthyroid control subjects (5.6±1.3pmolL −1 ) ( P <0.001). The correlation between the plasma adrenomedullin concentration and serum free thyroid hormone levels was marginally significant. The mean blood pressure was relatively low in the face of an elevated plasma adrenomedullin level. Adrenomedullin may therefore be responsible for the vasodilatation observed in thyrotoxicosis.